抗血小板治疗在老年慢性阻塞性肺疾病急性加重期患者中的效果观察

Effect observation of anti-platelet therapy in treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨老年慢性阻塞性肺疾病急性加重期(AECOPD)患者应用抗血小板治疗的效果。方法选取80例AECOPD患者,随机分为观察组与对照组各40例,对照组给予常规方法治疗,观察组在对照组基础上给予阿司匹林肠溶片抗血小板治疗,比较2组治疗效果。结果治疗后,2组患者白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)等炎性细胞因子水平较治疗前均显著降低(P<0.05),且观察组治疗后各指标均显著低于对照组(P<0.05)。治疗后,2组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV 1)、第1秒用力呼气容积与用力肺活量比值(FEV 1/FVC)及呼吸困难指数(mMRC)等指标较治疗前均显著改善(P<0.05),且观察组治疗后各指标改善程度显著优于对照组(P<0.05)。结论老年AECOPD患者采用抗血小板治疗安全、有效,能明显缓解患者炎症症状,改善患者肺功能及呼吸功能。

Objective The explore effect of anti-platelet therapy in treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Eighty patients with AECOPD were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with aspirin enteric-coated tablets on the basis of the control group.Therapeutic effect was compared between two groups.Results After treatment,the levels of interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and hypersensitive Creactive protein(hs-CRP)in both groups were significantly lower than those before treatment(P<0.05),and these indexes in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in the first second(FEV 1),ratio of FEV 1 to FVC(FEV 1/FVC)and modified British Medical Research Council(mMRC)in both groups significantly improved(P<0.05),and the improvement of each index in the observation group was significantly better than that in the control group(P<0.05).Conclusion The anti-platelet therapy is effective and safe in treatment of patients with AECOPD,which can significantly alleviate the inflammatory symptoms and improve the lung function and respiratory function.