丙泊酚对瑞芬太尼引起的痛觉过敏影响的研究进展

Research progress in the effect of propofol on remifentanil-induced hyperalgesia

丙泊酚是最常用的静脉麻醉药物之一,因具有起效快、作用时间短、苏醒快而完全、术后恶心呕吐发生率低、不良反应少等优点而广泛应用于临床麻醉。瑞芬太尼是一种超短效的多阿片受体激动剂,因具有镇痛作用强、起效快、代谢快且不受肝、肾功能影响的特点也广泛用于临床麻醉。在围手术期人群中,瑞芬太尼与痛觉过敏的发生关系密切,而丙泊酚与瑞芬太尼常联合用于全身麻醉,本文就近年丙泊酚对瑞芬太尼引起的痛觉过敏影响的研究进展进行综述。

Propofol is one of the most commonly used intravenous anesthetics.It is widely used in clinical anesthesia because of its advantages of rapid onset,short action time,quick and complete recovery,and low incidence of nausea and vomiting after operation.Remifentanil is an ultra-short-acting multi-opioid receptor agonist.It is also widely used in clinical anesthesia because of its strong analgesic effect,rapid onset,rapid metabolism and being not influenced by liver and kidney functions.Remifentanil is closely related to the occurrence of hyperalgesia during perioperative period,while propofol and remifentanil are often used in general anesthesia.This article reviews the research progress in the effect of propofol on remifentanil-induced hyperalgesia in recent years.