甲胎蛋白与癌胚抗原在不同类型消化道恶性肿瘤患者血清中的表达

Expressions of alpha fetoprotein and carcinoembryonic antigen in serum of patients with different types of gastrointestinal cancer

目的探讨甲胎蛋白(AFP)与癌胚抗原(CEA)在不同类型消化道恶性肿瘤患者血清中的表达以及联合检测的诊断价值。方法回顾性分析2015年3月—2018年2月在本院治疗的117例消化系统疾病患者的临床资料,依据组织学检查或病理检查结果,将入选者分为恶性肿瘤组70例与良性病变组47例,同时选取本院接受健康体检的30例健康志愿者为对照组。结果恶性肿瘤组患者AFP、CEA水平显著高于良性病变组患者与对照组(P<0.01)。肝癌组患者AFP水平显著高于结肠直肠癌、胰腺癌以及胃癌患者(P<0.01);肝癌患者CEA水平显著低于结肠直肠癌、胰腺癌以及胃癌患者(P<0.01)。在结肠直肠癌、胰腺癌、肝癌、胃癌患者中,AFP联合CEA的阳性检出率均显著高于AFP或CEA单一检测结果(P<0.05或P<0.01)。结论AFP与CEA在不同类型消化道恶性肿瘤中具有一定的诊断与鉴别诊断价值,二者联合可有效提高阳性检出率。

Objective To investigate the expressions of alpha fetoprotein(AFP)and carcinoembryonic antigen(CEA)in the serum of patients with different types of gastrointestinal cancer and the diagnostic value of combined detection of two indexes.Methods The clinical materials of 117 patients with digestive system diseases treated in our hospital from March 2015 to February 2018 were analyzed retrospectively.According to the results of histological examination or pathological examination,the selected patients were divided into malignant tumor group(n=70)and benign disease group(n=47).Meanwhile,30 healthy volunteers were selected as the control group.Results The levels of AFP and CEA in malignant tumor group were significantly higher than those in benign disease group and control group(P<0.01).The levels of AFP and CEA in liver cancer group were significantly higher than those in colorectal cancer group,pancreatic cancer group and gastric cancer group(P<0.01).In colorectal cancer,pancreaticcancer,liver cancer and gastric cancer,the positive rate of AFP combined with CEA was significantly higher than that of AFP or CEA alone(P<0.05 or P<0.01).Conclusion AFP and CEA have a certain value in the diagnosis and differential diagnosis of different types of digestive tract cancer.The combination of two indexes can effectively improve the positive detection rate.