黄芩茎叶总黄酮对高甘油三酯血症大鼠血脂的调节作用

Role of scutellaria baicalensis stem-leaf total flavonoid in regulating blood lipid level of rats with hypertriglyceridemia

目的探讨黄芩茎叶总黄酮(SSTF)对高甘油三酯血症大鼠血脂的调节作用。方法将36只SD大鼠适应性饲养1周后随机分为正常对照组、模型组、阳性对照组以及SSTF低、中、高剂量组。除正常对照组喂食普通饲料外,其他5组均喂食高脂饲料,并同时给予药物干预,其中阳性对照组给予非诺贝特100 mg/kg,SSTF低、中、高剂量组分别给予50、100、200 mg/kg的SSTF。给药前及药物干预6周末眼眶静脉丛取血,测定血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平。结果给予饲料喂养和药物干预6周后,SSTF低、中、高剂量组大鼠体质量显著低于模型组(P<0.05),但与正常对照组、阳性药物组相比无显著差异(P>0.05)。SSTF低、中、高剂量组大鼠血清TG、TC、LDL-C水平显著低于模型组(P<0.05),HDL-C水平显著高于模型组(P<0.05),但与阳性药物组相比无显著差异(P>0.05)。结论不同剂量SSTF均能有效控制高甘油三酯血症大鼠体质量的增长,降低高甘油三酯血症大鼠血清TG、TC、LDL-C水平,升高HDL-C水平,说明SSTF具有调血脂作用。

Objective To explore the role of scutellaria baicalensis stem-leaf total flavonoid(SSTF)in regulating blood lipid level of rats with hypertriglyceride.Methods Thirty-six SD rats were randomly divided into normal control group,model group,positive control group(fenofibrate)and low,medium and high doses of SSTF groups after one week of adaptive feeding.Except for the normal control group,the other five groups were fed with high-fat diet and given drug intervention at the same time.The positive control group was given fenofibrate 100 mg/kg,and the low,middle and high doses of SSTF groups were given 50,100 and 200 mg/kg of SSTF respectively.Blood samples were collected from orbital venous plexus before administration and 6 weeks after drug intervention.Serum levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were measured.Results After 6 weeks of feeding and drug intervention,the body weights of rats in low,medium and high doses of SSTF groups were significantly lower than that in model group(P<0.05),but there were no significant differences when compared with normal control group and positive control group(P>0.05).The serum levels of TG,TC and LDL-C in low,middle and high doses of SSTF groups were significantly lower than those in model group(P<0.05),and HDL-C was significantly higher than that in model group(P<0.05),but there were no significant differences when compared with positive control group(P>0.05).Conclusion Different doses of SSTF can effectively reduce the body weight increase of rats with hypertriglyceridemia,reduce the serum levels of TG,TC,LDL-C and increase the level of HDL-C,which indicate that SSTF has the effect of regulating blood lipid.