器官型口腔黏膜感染模型在宿主-微生物关系研究的应用与展望

The applications and perspectives of organotypic oral mucosal infection model in host-pathogen interactions study

构建体外口腔黏膜感染模型有助于研究口腔黏膜感染性疾病的发病机制与防治策略。器官型口腔黏膜感染模型以组织工程化口腔黏膜为基础,通过引入病原体提取物、接种浮游微生物或与细菌生物膜、唾液共培养,在体外模拟口腔微生物与宿主的相互作用。近年来,学者们通过该技术研究微生物对口腔黏膜疾病和牙周疾病的发生、发展作用及致病机理。本文将对器官型口腔黏膜感染模型的建立、研究进展与应用前景等进行阐述。

The construction of oral mucosa infection model in vitro is conducive to exploring the pathogenesis and prevention strategies of oral infectious diseases of oral mucosa.The organotypic oral mucosal infection model is based on the tissue⁃engineered oral mucosa,which is cocultured with the extraction of pathogens,planktonic microorganisms,biofilm or saliva,to mimic the interactions between the oral microbiome and the oral mucosa of the host.In recent years,researchers have used this technology to study the role of microbes in the development and pathogenesis of oral mucosal diseases and periodontal diseases.This article reviews the construction,recent advances and perspectives of the organotypic oral mucosa infection model.