人源性异种移植模型在胰腺癌个体化治疗研究中的应用

Application of Patient-Derived Xenograft Models for Personalized Treatment of Pancreatic Cancer

本文介绍了胰腺癌人源性异种移植(patient-derived xenograft,PDX)模型的基本特征、建模方法及模型应用中存在的问题,阐述了PDX模型在胰腺癌个体化药物筛选和耐药机制研究中的可行性。常规的胰腺癌标准化疗方案及联合用药疗效低下,因此,需要关注靶向重塑胰腺癌微环境抗肿瘤研究的重要性以期为研究者们提供新的思路,合理地使用该模型开展胰腺癌的研究,为胰腺癌患者提供更加高效的个体化治疗方案。

This paper introduces the basic characteristics and problems in modeling and the application of patient-derived xenograft(PDX) models for pancreatic cancer,and expounds the feasibility of PDX models in the study of individualized drug screening and drug resistance mechanism of pancreatic cancer. Conventional standard chemotherapy and combination therapy regimens for pancreatic cancer are less effective. Therefore, it is necessary to pay attention to the importance of targeting and remodeling the anti-tumor study of pancreatic cancer microenvironment so that it can provide new ideas for researchers, reasonably use this model to carry out pancreatic cancer research,and provide more efficient personalized treatment for patients with pancreatic cancer.