老年糖尿病患者颈动脉斑块形成与血糖水平相关性研究

Relationship between carotid plaque formation and blood glucose level in elderly patients with diabetes mellitus

目的探讨老年糖尿病患者颈动脉斑块形成与血糖水平的关系。方法选择老年糖尿病患者84例,均行彩色多普勒超声,根据颈动脉斑块情况分为有斑块组与无斑块组。有斑块组根据斑块等级又分为斑块Ⅰ级组、Ⅱ级组、Ⅲ级组。测定患者糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖水平。分析血糖水平对颈动脉斑块形成的影响。结果有斑块组的HbA1c、FPG、餐后2 h血糖水平均高于无斑块组,差异有统计学意义(P<0.05)。斑块Ⅱ级组、Ⅲ级组的HbA1c、FPG、餐后2 h血糖均高于斑块Ⅰ级组(P<0.05),随着斑块严重程度的增加,血糖水平逐渐升高。结论老年糖尿病患者血糖水平与颈动脉斑块的发生、发展具有相关性,血糖控制良好有助于延缓动脉硬化的进展。

Objective To investigate relationship between carotid plaque formation and blood glucose level in elderly patients with diabetes mellitus.Methods A total of 84 elderly patients with diabetes mellitus were collected and conducted with color Doppler ultrasound.According to the status of carotid plaque,the patients were divided into plaque group and non-plaque group.According to the plaque grade,the plaque group was divided into gradeⅠgroup,gradeⅡgroup and gradeⅢgroup.Glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG)and 2 hours postprandial blood glucose were measured.The effect of blood glucose level on carotid plaque formation was analyzed.Results HbA1c,FPG and 2 hours postprandial blood glucose in the plaque group were significantly higher than those in the non-plaque group(P<0.05).HbA1c,FPG and 2 hours postprandial blood glucose in gradeⅡand gradeⅢplaque groups were significantly higher than those in gradeⅠplaque group(P<0.05).With the increase of plaque severity,the blood glucose level gradually increased.Conclusion There is a correlation between the level of blood glucose and the occurrence and development of carotid plaque in elderly diabetic patients.Good blood glucose control is helpful to delay the progress of atherosclerosis.