手持式拉曼光谱快速鉴别部分头孢菌素类原料

Rapid Identification of Some Cephalosporins API by Handheld Raman Spectrometer

建立手持式拉曼快速鉴别部分头孢菌素类原料方法。方法:采用对照品建立拉曼光谱图库,用命中率指数(hit quality index,HQI)进行评价。结果:阳性样品HQI均大于0.98,阴性样品的HQI均小于0.90,420批样品验证鉴定正确率100%。结论:手持式拉曼光谱仪方法简便、准确,可以用于头孢菌素类企业生产快速鉴别。

To establish a handheld Raman spectrometer method for rapid identification of some cephalosporins API.A Raman spectral library was constructed by reference substance,and the hit quality index(HQI)was used for evaluation.Results:The HQI of positive samples was greater than 0.98 and the negative samples was less than 0.90.Correct rate of identification of 420 batch samples was 100%.The method of handheld Raman spectrometer is simple and accurate,and can be used for rapid identification in cephalosporins production.