亚临床甲状腺功能亢进与心房颤动的相关性

Subclinical hyperthyroidism and its association with atrial fibrillation

目的探讨亚临床甲状腺功能亢进(亚临床甲亢)与心房颤动之间的相关性。方法选取在我院行甲状腺功能检查并诊断为亚临床甲亢的住院患者388例,随机选取住院期间行甲状腺功能检查并诊断为甲状腺功能亢进和甲状腺功能正常患者各388例作为甲亢对照组和正常对照组,比较三组间一般情况、TSH水平和房颤发病率;根据是否房颤,将入组患者分为房颤组与非房颤组,比较两组间TSH水平;采用Spearman秩相关分析TSH水平与房颤发病率的相关性;采用Logistic回归对房颤的危险因素进行分析。结果①房颤发病率三组间差异及两两比较差异均有统计学意义(3.22%vs.17.78%vs.12.90%,P均<0.05);②房颤组的TSH水平明显低于非房颤组[0.14(0.13,0.23)vs.0.20(0.09,2.59),P<0.01];③Spearman秩相关分析,TSH水平与房颤呈负性相关,r=-0.162(P<0.01);④Logistic回归分析,年龄、亚临床甲亢、糖尿病3个指标为房颤的独立危险因素,OR值分别为1.29、2.03、1.79(P均<0.05)。结论亚临床甲亢是房颤的独立危险因素,建议亚临床甲亢患者早期行相关检查对房颤进行诊治。

Objective To explore the association of subclinical hyperthyroidism(SCH)with atrial fibrillation(AF).Methods Three hundred and eighty-eight patients with SCH diagnosed by thyroid function examination in our hospital were selected as SCH group,388 inpatients with hyperthyroidism were selected randomly as hyperthyroidism group while 388 inpatients with normal thyroid function were selected randomly as normal group.General information,TSH levels and incidence of atrial fibrillation were compared among the three groups.Serum TSH levels were compared between AF group and non-AF group.Correlation between TSH level and incidence of AF was analyzed with the methods of Spearman.Logistic regression analyses were performed to identify the independent risk factors for AF.Results①There were significant differences in the incidence of AF among the three groups(3.22%vs.17.78%vs.12.90%,P<0.05);②TSH level of AF group was significantly lower than non-AF group[0.14(0.13,0.23)vs.0.20(0.09,2.59),P<0.01];③Spearman sequential correlation analysis demonstrated that TSH was negatively correlated with AF,r=-0.162(P<0.01);④Logistic analyses demonstrated that age,SCH and diabetes were independently associated with AF(OR=1.29,2.03,1.79,P<0.05).Conclusion SCH was independently associated with AF.Early diagnosis and treatment of AF are advised in patients with SCH.