亚洲人群FTO-rs9939609多态性与T2DM相关性分析

Analysis of the Association Between FTO-rs9939609 Polymorphism and Type 2 Diabetes in Asian Population

目的探讨亚洲人群FTO基因rs9939609T> A多态性与2型糖尿病(T2DM)的相关性。方法通过检索Pubmed、EMbase、CNKI、万方数等据库,查找关于FTO基因与T2DM相关性的病例对照研究,检索时限为2010年1月-2018年11月。对文献的质量进行评价和资料提取,利用State12.0软件合并OR值及95%可信区间(CI),评估符合质量标准文献FTO基因rs9939609 T> A多态性与2型糖尿病(T2DM)的相关性。结果共纳入文献8篇,累计样本量7 768例(T2DM病组3 867例,对照组3 901例)。Meta分析结果显示亚洲地区人群FTO基因rs9939609 AA型与2型糖尿病相关(OR=1.25,95%CI:1.16~1.34)。进一步对病例亚分组,东亚及中国地区人群rs9939609 AA型与T2DM同样具有相关性(东亚:OR=1.26,95%CI:1.13~1.38;中国:OR=1.29,95%CI:1.13~1.45);而南亚地区合并OR=1.16,95%CI:0.83~1.48,不具有相关性。发表偏倚评估显示无发表偏倚。结论亚洲人群中FTO基因rs9939609 AA型与2型糖尿病具有相关性,增加了T2DM的发病风险。

Objective To investigate the association between FTO gene rs9939609 t > A polymorphism and type 2 diabetes mellitus(T2 DM) in Asian population.Methods Through searching PubMed,EMBASE,CNKI,Wanfang and other databases,we can find the case-control study on the correlation between FTO gene and T2 DM,and the retrieval time limit is from January 2010 to November 2018.To evaluate the quality of the literature and extract the data,using state12.0 software combined with or value and 95% confidence interval(CI),to evaluate the association between the polymorphism of FTO gene rs9939609 T > A and type 2 diabetes mellitus(T2 DM).Results The total number of samples was 7 768(3 867 in T2 DM group and 3 901 in control group).Meta analysis showed that the FTO gene rs9939609 AA was associated with type 2 diabetes mellitus(OR = 1.25,95% CI:1.16 ~ 1.34).Further to the case subgroups,there was also a correlation between rs9939609 AA and T2 DM in East Asia and China(East Asia:OR = 1.26,95% CI:1.13 ~ 1.38;China:OR = 1.29,95% CI:1.13 ~ 1.45).However,there was no correlation between OR = 1.16 and 95% CI:0.83 ~ 1.48 in South Asia.The publication bias assessment showed no publication bias.Conclusion The FTO gene rs9939609 AA is associated with type 2 diabetes in Asian population,which increases the risk of T2 DM.