节律基因与肿瘤相关性研究进展

Research Progress on Correlation of Circadian Genes and Tumors

昼夜节律是机体长期适应外界环境变化所产生的内在机制,许多生命活动例如细胞增殖、细胞代谢、激素分泌等均与昼夜节律相关。机体通过节律基因调节生命活动,使其保持有序性和协同性。近年来,节律基因研究不断深入,发现其异常表达与肿瘤进程有着密切联系。该文将主要从节律基因的调控通路,节律基因在肿瘤中的表达,节律基因与细胞周期、细胞代谢、癌基因的关联,以及节律基因在肿瘤治疗中的应用现状这六个方面揭示节律基因与肿瘤发展与治疗的关联,并从肿瘤休眠的视角进行展望,为肿瘤与昼夜节律的相关研究提供思路。

Circadian rhythm is an endogenous regulatory mechanism of organism under long-term adaptation to the environmental changes.Many life activities are regulated by circadian rhythm such as cell proliferation,cell metabolism,hormone secretion,etc.The organism orchestrates life activities through the oscillating expression of circadian genes.Recently,with more researches in circadian genes,it has been found that the dysregulation of circadian genes is closely related to the tumor progression.In this review,the relationship between circadian genes and tumor progression and tumor therapy is discussed from six aspects:biological circadian gene regulation pathway,expression of circadian genes in tumor,the relationships between circadian genes and cell cycle,cell metabolism,oncogenes,and the application of circadian genes in tumor therapy.The potential application of circadian regulation is also discussed from the perspective of tumor dormancy,to provid new sight for researches related to tumors and circadian rhythm.