四川地区一般人群不同月份维生素D营养状况的初步分析

Preliminary analysis of nutritional status of vitamin D in the general populations in Sichuan province

目的探讨四川地区一般人群血清25-羟基维生素D(25OHD)水平和维生素D的营养状况,并分析其在不同性别、年龄和月份的变化情况。方法对14645例来源于四川地区的一般人群,通过电化学发光法检测其血清25OHD水平,定义血清25OHD>30 ng/mL为正常;20 ng/mL≤25OHD≤30 ng/mL为不足;25OHD<20 ng/mL为缺乏。根据性别和年龄进行分组,分别统计各组25OHD水平、维生素D营养状况,并分析其不同月份的变化趋势。结果受试者血清25OHD平均水平为(22.12±10.95)ng/mL;维生素D缺乏、不足和正常的比例分别为50.45%、32.14%和17.41%;男性组维生素D缺乏明显低于女性组,男性维生素D正常率明显低于女性组,男性组人群血清25OHD水平高于女性组;<18岁、≥60岁、45~<60岁和18~<45岁人群组维生素D缺乏率分别为29.02%、47.37%、55.91%和64.57%;1月人群维生素D正常率最低(8.34%),7月最高(26.02%),1—7月人群维生素D正常率逐渐升高,7月之后呈下降趋势;2月人群血清25OHD水平最低为(17.43±9.99)ng/mL,7月份达到最高(25.56±11.67)ng/mL。结论四川地区一般人群血清25OHD水平偏低,维生素D不足和缺乏在人群中非常普遍,尤其是在18~<45岁人群和女性人群中,不同月份人群25OHD水平和缺乏率差异较大。

Objective To explore the serum levels of 25-hydroxyvitamin D and the nutritional status of vitamin D in the general population in Sichuan,and to analyze the changes in the different sexes,different ages and in different months.Methods The serum concentration of 25-hydroxyvitamin D(25OHD)was determined by electrochemiluminescence in 14862 patients.The cutoff points that we used was 20 ng/mL.The deficiency level of serum 25OHD<20 ng/mL,the insufficiency of viatamin D(20~30 ng/mL).And the serum 25OHD>30 ng/mL was divided as normal.According to gender and age,the 25OHD concentration levels and the percentage of normal,insufficient and deficiency vitamin D in the population of each group were counted separately,and the trends of different months were analyzed.Results The average serum 25OHD level was(22.12±10.95)ng/mL in this study.The deficiency,insufficient and normal of vitamin D in the population accounted for 50.45%,32.14%and 17.41%,respectively.The vitamin D deficiency rate in the male group was significantly lower than that in the female group.The normal rate of vitamin D in the male group was significantly lower than that in the female group.The serum 25OHD concentration in the male group was higher than that in the female group.The vitamin D deficiency rates of<18 years old,≥60 years old,45-<60 years old and 18-<45 years old were 29.02%,47.37%,55.91%,and 64.57%,respectively.From January to July,the normal rate of vitamin D gradually increased,and after July,it showed a downward trend.The normal rate of vitamin D in the population was the lowest in January,only 8.34%,the highest in July was 26.09%.The lowest concentration of 25OHD was(17.43±9.99)ng/mL in February.The highest in July(25.56±11.67)ng/mL.Conclusion The serum 25OHD concentration in the general population in Sichuan is low.Vitamin D deficiency and insufficient prevail in the population,especially in the 18-<45 age group and in females.The population has different vitamin D concentration and normal rate in different months.