类天疱疮群流行病学及致病因素

Epidemiology and related pathogenesis factors of pemphigoid diseases

类天疱疮群是一组由自身抗体攻击基底膜带抗原蛋白,导致真表皮分离、表皮下水疱的自身免疫性疱病。该群组包含大疱性类天疱疮、黏膜类天疱疮等多个疾病,其中大疱性类天疱疮最为常见。不同国家和地区的类天疱疮发病特点不同,有些类天疱疮的病因和发病机制尚不明确。本文对几种较常见类天疱疮的流行病学特征及可能致病因素进行综述,为疾病的干预提供新视角。

Pemphigoid is one group of diseases characterized by binding of autoantibodies to components of hemi-desmosome structure,resulting in separation of epidermis and dermis,and sub-epidermal blister formation. This group of disease includes various pemphigoids, such as bullous pemphigoid( BP), mucous membrane pemphigoid( MMP) and other different types,while BP is the most common type. The characteristics of pemphigoids differ among patients from different regions or countries. However,the pathogenesis of some kinds of pemphigoids is still unclear. The epidemiological characteristics,potential pathogenesis risk factors for several kinds of common pemphigoids were summarized in this article,providing new insight into disease intervention.