稳定期精神分裂症患者血清炎性因子与临床精神症状的相关性研究

Correlation between serum inflammatory factors and clinical psychiatric symptoms in patients with stable schizophrenia

目的分析稳定期精神分裂症患者血清炎性因子与临床精神症状的相关性,探讨血清炎性因子对稳定期精神分裂症的影响。方法测定126例精神分裂症患者(精神分裂症组)及50名健康体检者(对照组)的血清中白细胞介素(IL)-1β、IL-6、IL-12、肿瘤坏死因子(TNF)-α等炎性因子指标,并采用阳性和阴性症状量表(PANSS)评估患者临床精神症状。根据PANSS评分将精神分裂症组患者分为稳定期组(52例)、非稳定期组(76例)。分析各组血清炎性因子与临床精神症状的相关性。结果与非稳定期组比较,稳定期组PANSS量表中阳性症状、阴性症状及一般精神病理症状评分均明显下降(P<0.05)。与对照组比较,稳定期组血清IL-6、IL-12、TNF-α水平明显升高,差异均有统计学意义(P<0.05);与稳定期组比较,非稳定期组血清IL-1β、IL-6、IL-12、TNF-α水平均显著升高(P<0.05)。稳定期组患者阳性症状、阴性症状、一般精神病理症状与IL-6、IL-12、TNF-α均呈正相关,而与IL-1β与无相关(P>0.05)。非稳定期组患者阳性症状、阴性症状、一般精神病理症状与血清IL-1β、IL-6、IL-12、TNF-α均呈正相关(P<0.05)。结论稳定期精神分裂症患者存在不同程度的慢性炎症反应,且与临床精神症状密切相关,参与了精神分裂症的病情发展。

Objective To investigate the correlation between serum inflammatory factors and clinical psychiatric symptoms in patients with stable schizophrenia,and to explore the effect of serum inflammatory factors on stable schizophrenia.Methods Inflammatory factors including serum levels of interleukin(IL)-1β,IL-6,IL-12,TNF-αwere measured in 126 patients with schizophrenia(schizophrenia group)and 50 healthy patients(control group),and the positive and negative symptom scales(PANSS)were used to evaluate clinical psychiatric symptoms.According to PANSS score,patients in the schizophrenia group were divided into stable group(n=52)and non-stable group(n=76).The correlation between serum inflammatory factors and clinical psychiatric symptoms was analyzed.Results Compared with the non-stable group,the PANSS score of positive symptoms,negative symptoms and general psychopathological symptoms were significantly decreased in the stable group(P<0.05).Compared with the control group,serum levels of IL-6,IL-12 and TNF-αin the stable group were significantly increased(P<0.05).Compared with the stable group,serum levels of IL-1β,IL-6,IL-12 and TNF-αin the non-stable group were significantly increased(P<0.05).Positive,negative and general psychopathological symptoms were positively correlated with IL-6,IL-12 and TNF-α,while IL-1βwas not significantly correlated(P>0.05).Positive,negative and general psychopathological symptoms were significantly positively correlated with serum IL-1β,IL-6,IL-12 and TNF-αin the non-stable group(P<0.05).Conclusions Patients with stable schizophrenia have different degrees of chronic inflammatory reactions,which are closely related to clinical psychiatric symptoms and participating in the disease development of schizophrenia.