芪苈强心胶囊联合腺苷三磷酸(ATP)敏感性钾通道开放剂对冠心病心绞痛患者症状改善及心电图变化的影响

Effect of Qili Qiangxin Capsule combined with adenosine triphosphate(ATP)sensitive potassium channel opener on symptom improvement and electrocardiogram changes in patients with angina pectoris of coronary heart disease

目的研究芪苈强心胶囊联合腺苷三磷酸(ATP)敏感性钾通道开放剂对冠心病心绞痛患者症状改善及心电图变化的影响。方法选取我院冠心病心绞痛患者102例(2017年7月-2019年2月),简单随机化分组。参照组(51例)实施ATP敏感性钾通道开放剂治疗,联合组(51例)实施芪苈强心胶囊+ATP敏感性钾通道开放剂治疗,两组疗程均为8周。对比两组心电图疗效、症状改善及治疗前后血清基质金属蛋白酶-9(MMP-9)、超氧化物歧化酶(SOD)水平。结果联合组心电图总有效率(94.12%)高于参照组(80.39%),P<0.05;联合组治疗8周后心绞痛发作频次较参照组少,心绞痛持续时间较参照组短(P<0.001);联合组治疗8周后血清MMP-9水平较参照组低,血清SOD水平较参照组高(P<0.001)。结论芪苈强心胶囊联合ATP敏感性钾通道开放剂治疗冠心病心绞痛,能明显增强心电图疗效,减少心绞痛发作频次,缩短心绞痛持续时间,调节血清MMP-9、SOD水平,抑制心室重构。

Objective To study the effect of Qili Qiangxin Capsule combined with adenosine triphosphate(ATP)sensitive potassium channel openers on symptom improvement and electrocardiogram(ECG)changes in patients with angina pectoris of coronary heart disease.Methods A total 102 patients with coronary heart disease and angina pectoris in our hospital(July 2017 to February 2019)were randomly assigned.Patients in the reference group(51 cases)were treated with ATP sensitive potassium channel openers,and patients in the combined group(51 cases)were given Qili Qiangxin Capsule+ATP sensitive potassium channel openers.The treatment course of two groups was 8 weeks.The electrocardiogram efficacy,symptom improvement and serum matrix metalloproteinase 9(MMP 9)and superoxide dismutase(SOD)levels before and after treatment in the 2 groups were compared.Results The total effective rate of electrocardiogram in the combined group(94.12%)was higher than that in the control group(80.39%),P<0.05.After 8 weeks of treatment,the frequency of angina pectoris attack in the combined group was less than that in the control group,and the duration of angina pectoris was shorter than that in the control group(P<0.001).After 8 weeks of treatment,the serum MMP 9 level in the combined group was lower than that in the control group,and the serum SOD level was higher than that in the control group(P<0.001).Conclusion Qili Qiangxin Capsule combined with ATP sensitive potassium channel openers in the treatment of angina pectoris of coronary heart disease can significantly enhance the outcome in electrocardiogram,reduce the frequency of angina pectoris attack,shorten the duration of angina pectoris,regulate the levels of serum MMP 9 and SOD and inhibit ventricular remodeling.