细菌生物膜与慢性创面感染

Bacterial biofiim and chronic wound infection

细菌通常以生物膜的形式在慢性创面上定植、繁殖和侵袭性生长。有别于游离细菌,生物膜内的细菌在表观遗传学、生物学行为,特别是对抗抗生素和宿主免疫等方面均展现岀独特的机制。本文介绍了细菌生物膜的组成和结构功能,阐述了细菌生物膜的耐药机制,论述了细菌生物膜感染创面的临床表现特点及生物膜的诊断方法,分析了针对细菌生物膜的治疗策略。谨以此文提示临床医师重视细菌生物膜感染,提倡对细菌生物膜进行深入研究,以提高慢性创面的治疗质量。

Bacteria usually colonize,reproduce,and grow aggressively on chronic wounds in the form of biofilm.Different from free bacteria,bacteria in biofilm exhibit unique mechanism in epigenetics and biological behavior,especially in resistance to antibiotics and host immunity.In this article,we introduce the composition and structural function of bacterial biofilm,expound the drug-resistance mechanism of bacterial biofilm,discuss the clinical characteristics of bacterial biofilm infection wound and the diagnosis method of biofilm,and analyze the treatment strategy for bacterial biofilm.It is suggested that clinicians should pay more attention to bacterial biofilm infection and advocate in-depth study of bacterial biofilm in order to improve the quality of managing chronic wounds.