摘要
C-C键断裂在有机合成中有着重要的作用.报道了一种胺促进的α-卤代酮化合物C-C键断裂的新方法,该方法无需使用过渡金属催化剂以及氧化剂.采用这种方法以廉价的α-卤代酮化合物制备了多种α-乙酰氧基芳基酮化合物.
The cleavage of C-C bonds is a key method for synthesis of useful intermediates. A novel amine-promoted C-C bond cleavage of α-halo ketones was reported. Oxidant-free and metal-free conditions are the striking features of the protocol. In this simple method, a variety of α-acetoxyaryl ketone compounds were prepared from commercially available α-halo ketones in good to excellent yields.
作者
王毛锐
吴雨峥
姚健
邓黎
潘英明
黄克斌
唐海涛
Wang Maorui;Wu Yuzheng;Yao Jian;Deng Li;Pan Yingming;Huang Kebin;Tang Haitao(State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin,Guangxi 541004)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第11期3223-3229,共7页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(No.21362002)
the Bagui Scholar Program of Guangxi Province of China(No.2016A13)~~