摘要
研究了铜催化的脱羰环化生成靛红的方法,使用氧气作为最终的氧化剂.这个互补的C(sp3)-H官能团化方法为合成靛红提供了一种新方案.Cu/O2/Co体系显示出良好的反应性和兼容性,富电子和缺电子的官能团都可以很好地兼容.并基于机理研究和以前的文献报道,提出了一个可能的假设机理.
A copper-catalyzed decarbonylation cyclization to form isatins using oxygen as terminal oxidant is developed. This complementary way offers a new protocol for the synthesis of isatins through C(sp3)-H bond functionalization in Cu/O2/Co system. This system shows good reactivity and compatibility. Both electron-rich and electron-deficient functional groups can be tolerated. A postulated mechanism is proposed based on mechanistic studies and previous reports.
作者
Ahmad,Muhammad Siddique
主亚敏
郭云龙
张赛赛
沈增明
Ahmad Muhammad Siddique;Zhu Yamin;Guo Yunlong;Zhang Saisai;Shen Zengming(School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第11期3244-3249,共6页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Sciences Foundation of China(No.21672144)~~
关键词
铜催化
碳氢键活化
靛红
脱羰
氧气
Cu catalyst
C-H bond activation
isatin
decarbonylation
oxygen
