OSA与肠道微生态平衡研究相关进展

Progress in studies on obstructive sleep apnea and intestinal microecological balance

OSA是以睡眠时反复出现的打鼾、呼吸暂停导致低氧灌注间断反复发作,并以白天嗜睡、神志精神异常等为主要表现的睡眠呼吸障碍性疾病。由于OSA引起的反复间歇性低氧、二氧化碳潴留所致高碳酸血症以及睡眠结构的失调,可引起机体生理功能的紊乱,进而引发的一系列并发症。目前有研究报道指出,OSA与多种疾病的发生发展具有极为密切的关系。

Obstructive sleep apnea(OSA) is closely related to the development of various diseases. Hypoxic perfusion caused by OSA can mediate the occurrence of inflammatory reactions or aggravate metabolic disorders to affect intestinal microecological balance. Intestinal bacteria can participate in the development of inflammatory reaction or metabolic disorder by itself or its components, and the oxidative stress reaction of the body develops in a vicious circle. The mechanism has not yet been fully elucidated, so we reviewed the research progress on OSA and intestinal microecological balance.