甲状腺激素及自身抗体水平与慢性自发性荨麻疹的关系

The association of thyroid hormone and thyroid autoantibodys level with chronic spontaneous urticaria

目的探讨甲状腺激素水平及甲状腺自身抗体与慢性自发性荨麻疹(CSU)之间的关系。方法收集2016年2月一2017年9月在安徽省第二人民医院就诊的186例慢性荨麻疹患者,以同期124例健康体检者作为对照。电化学发光免疫分析法测定血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)、甲状腺微粒体抗体(TMAb)水平。结果单因素分析显示血清FT4水平CSU组显著高于对照组,TGAb、TPOAb、TMAb阳性率CSU组显著高于对照组(P<0.05)。Logistic回归分析显示校正了其他因素后,TGAb阳性者发生慢性荨麻疹的风险是TGAb正常者1.92倍(95% CI=1.12〜3.33);TMAb阳性者发生慢性荨麻疹的风险是TMAb正常者1.62倍(95% CI=1.05〜2.48);TPOAb阳性与CSU患者之间无统计学关联(P>0.05)。结论部分慢性荨麻疹发病与甲状腺自身抗体有关。

Objective To explore the association of thyroid hormone and thyroid autoantibodys level with chronic spontaneous urticaria(CSU).Methods One hundred and eighty-six cases of chronic urticaria were collected from February 2016 to September 2017 in Anhui Provincial Second People's Hospital,and 124 health examinees in the same period were collected as control.Serum levels of free triiodothyronine(FT3),free thyroxin(FT4),thyroid stimulating hormone(TSH),thyroglobulin antibody(TGAb),anti-thyroid peroxidase antibody(TPOAb),and thyroid microsome antibody(TMAb)were measured by electroluminescence immunoassay.Results Results from univariate analysis indicated that the serum FT4 level of the CSU group was significantly higher than that of the control group,and the antibody positive rate of TGAb,TPOAb and TMAb in the CSU group was significantly higher than that of the control group(P<0.05).After adjusting for other factors,the results from logistic regression analysis indicated that the risk of chronic urticaria in TGAb positive patients was 1.92 times higher than that in TGAb normal patients(95% CI=1.12-3.33),and the risk of chronic urticaria in patients with TMAb positivity was 1.62 times higher than that in patients with TMAb normality(95%CI=1.05-2.48).There was no statistical association between TPOAb positivity and CSU patients(P>0.05).Conclusion Chronic urticaria was related to thyroid autoantibodies.