摘要
目的:探讨程序性死亡配体-1(PD-L1)的表达与膀胱癌分级、分期和复发的关系。方法:收集哈尔滨医科大学附属第一医院泌尿外科膀胱癌患者211例作为膀胱癌组,选取膀胱憩室患者23例作为非肿瘤组进行对照。行免疫组化染色检测样本中PD-L1蛋白的表达情况。对膀胱癌患者的复发情况进行随访。结果:PD-L1在非肿瘤组中不表达,在膀胱癌组中有表达。随着膀胱癌分期和分级的进展,PD-L1在患者中的表达率逐步增加,其表达强度也逐步增强。随访结果表明,有PD-L1表达的膀胱癌患者,膀胱癌复发的时间更短。结论:PD-L1的表达与膀胱癌分级、分期和复发密切相关。PD-L1在膀胱癌的发生、发展、复发过程中起到了重要作用,有望成为膀胱癌治疗的重要靶点。
Objective: To investigate the correlation between PD-L1 protein expression and the grade, stage and relapse of bladder cancer. Method: A total of 211 surgical specimens of bladder cancer were collected from the department of urology, First Affiliated Hospital of Harbin Medical University. A total of 23 specimens of bladder diverticulum were collected as control group(no tumor). PD-L1 protein expression was measured by immunohistochemistry. Patients’ relapse rate were followed up. Result: PD-L1 did not express in normal tissues. With the development of the bladder cancer, the expression of PD-L1 got higher. Patients with higher level of PD-L1 expression relapsed more easily. Conclusion: PD-L1 protein expression is related to the grade, stage and relapse of bladder cancer. PD-L1 might be associated with the generation, development and relapse of bladder cancer, which can be used as the target of the treatment of bladder cancer.
作者
陈庭利
刘健男
安瑞华
CHEN Tingli;LIU Jiannan;AN Ruihua(Harbin Medical University,Harbin,150001,China;Department of Urology,First Affiliated Hospital of Harbin Medical University)
出处
《临床泌尿外科杂志》
2019年第11期908-910,915,共4页
Journal of Clinical Urology