大剂量盐酸氨溴索注射液联合无创机械通气治疗轻度新生儿呼吸窘迫综合征的疗效观察

Efficacy of high-dose Ambroxol hydrochloride injection combined with non-invasive mechanical ventilation in the treatment of mild neonatal respiratory distress syndrome

目的观察大剂量盐酸氨溴索注射液联合无创机械通气(CPAP)治疗轻度新生儿呼吸窘迫综合征(NRDS)的效果。方法选取2014年6月-2019年1月江西省高安市人民医院收治的轻度NRDS患儿60例,按照入院顺序随机分为试验组与对照组各30例。对照组采用CPAP治疗,试验组采用大剂量盐酸氨溴索注射液联合CPAP治疗。比较2组治疗前后血气分析指标[动脉血二氧化碳分压(PaCO2)、氧合指数(PaO2/FiO2)、动脉血氧饱和度(SaO2)]及并发症发生情况。结果治疗后2组患儿PaO2/FiO2及SaO2均高于治疗前,试验组高于对照组;PaCO2均低于治疗前,试验组低于对照组,差异均有统计学意义(P均<0.05)。试验组并发症发生率为3.33%低于对照组的23.33%,差异有统计学意义(χ^2=5.192,P<0.05)。结论大剂量盐酸氨溴索注射液联合CPAP治疗轻度NRDS可明显改善患儿症状,提升患儿呼吸功能,且相关并发症少,安全性高。

Objective To observe the effect of high-dose ambroxol hydrochloride combined with non-invasive mechanical ventilation(continuous positive airway pressure,CPAP)in the treatment of mild neonatal respiratory distress syndrome(NRDS).Methods 60 children with mild NRDS admitted to the Gao’an People’s Hospital,from June 2014 to January 2019 were selected.According to the order of admission,they were randomly divided into the experimental group and the control group,each of 30 cases.The control group was treated with CPAP,and the experimental group was treated with high-dose ambroxol hydrochloride injection combined with CPAP.Blood gas analysis indexes before and after treatment:arterial blood carbon dioxide partial pressure(PaCO2),pxygenation index(PaO2/FiO2)arterial oxygen saturation(SaO2),and complications were comparaed.Results After treatment,PaO2/FiO2 and SaO2 were higher in the two groups than before treatment,the test group was higher than the control group;PaCO2 was lower than before treatment,and the test group was lower than the control group,the difference were statistically significant (P<0.05).The complication rate was 3.33%lower than that of the control group(23.33%),the difference was statistically significant(χ^2=5.192,P<0.05).Conclusion High-dose ambroxol hydrochloride combined with CPAP in the treatment of mild NRDS can significantly improve the symptoms of children,improve the respiratory function of children,has fewer related complications and higher safety.