结直肠癌抑郁患者的静息态脑功能低频振幅研究

Amplitude of low-frequency fluctuations of resting-state functional MRI in colorectal cancer patients with depression

目的 探讨结直肠癌患者出现抑郁症状后的全脑自发性神经活动改变.方法 对33例结直肠癌抑郁患者(病例组)和43名健康受试者(对照组)进行静息态功能磁共振成像(rs-fMRI)扫描,计算低频振幅(ALFF)和分数低频振幅(fALFF),应用DPABI软件的统计模块行两独立样本t检验两组的ALFF和fALFF,将差异有统计学意义脑区的ALFF和fALFF值与病人健康问卷9(PHQ-9)评分和广泛焦虑量表7(GAD-7)评分进行相关分析.结果 与对照组比较,病例组双侧楔前叶、距状回、舌回、左侧楔叶、枕上回、枕中回、枕下回及右侧梭状回的ALFF值和fALFF值显著减低(t=-5.730,P<0.05;t=-4.872,P<0.05).这些脑区的ALFF和fALFF值与PHQ-9评分和GAD-7评分均无相关性(均P>0.05).结论 结直肠癌抑郁患者在静息状态下存在枕、顶叶局部脑区自发性神经活动减低,可能是结直肠癌抑郁患者的潜在神经生物学标记.

Objective To investigate the alterations of the cerebral resting-state spontaneous neural activity in colorectal cancer patients with depressive symptoms.Methods Thirty-three colorectal cancer patients(patient group)with depression and 43 healthy subjects(control group)underwent the resting state functional magnetic resonance imaging(rs-fMRI).The amplitude of low-frequency fluctuations(ALFF)and fractional ALFF(fALFF)were calculated.Two independent samples t test were used to compare the ALFF and fALFF values between two groups by DPABI software,and then correlation analysis was performed between ALFF and fALFF with statistical significance and Patient Health Questionnaire(PHQ-9)scores and Generalized Anxiety Disorder(GAD-7)scores.Results Compared with the control group,the patient group showed significantly lower ALFF and fALFF values in the bilateral precuneus,calcarine gyrus,lingual gyrus,left cuneus,superior,middle,inferior occipital gyrus and right fusiform gyrus(t=-5.730,P<0.05;t=-4.872,P<0.05).There were no significant correlations between the ALFF and fALFF values in these regions and PHQ-9 or GAD-7 scores(P>0.05).Conclusion Spontaneous decrease of neural activity in occipital and parietal lobes exists in colorectal cancer patients with depression at resting-sate,which may be a potential neurobiological marker.