单纯疱疹病毒性角膜基质炎角膜新生血管的研究进展

Research progress of corneal neovascularization in herpes stromal keratitis

单纯疱疹病毒性角膜基质炎(HSK)是由单纯疱疹病毒感染角膜深部基质所引起的免疫性疾病,伴有角膜免疫-炎性反应损伤以及新生血管形成,最终引起角膜混浊和视力下降。HSK容易反复发作,引起角膜基质的慢性炎性反应。新生血管在HSK病理过程中起关键作用,抑制新生血管形成将有助于控制疾病发展。本文针对HSK的病理机制、角膜新生血管形成过程中各细胞因子和调节因子的作用以及角膜新生血管可能的预防和控制方法,对最新研究进展进行汇总和分析,以期为临床研究提供参考。

Herpes simplex virus(HSV)infection can cause inflammatory reactions and angiogenesis of the cornea,which significantly reduce corneal transparency.Herpes stromal keratitis(HSK)is an immune mediated disease caused by HSV infection,and is associated with inflammation and angiogenesis of the cornea.It is difficult to control HSK therapeutically.Repeated episodes of HSK can result in chronic inflammatory disease in the corneal stroma.Neovascularization plays a key role in the pathogenesis of HSK,so inhibiting the angiogenesis will help to control HSK disease.In this review,the pathomechanism of HSK is described.The roles of multiple cytokines and soluble mediators in corneal vascularization are discussed,and the potential ways of preventing and controlling corneal vascularization induced by HSK are summarized.