神经内分泌网络在偏头痛共病抑郁中的研究进展

Advances in neuroendocrine networks in the study of migraine comorbid depression

偏头痛是一类临床最常见的具有致残性的原发性头痛,在我国人群的发病率为9.3%,女性与男性发病比率为3∶1,严重地影响了人们的生活质量.抑郁是偏头痛共病精神疾病中最常见的一种,与非偏头痛患者相比,偏头痛患者共病抑郁的风险高出2.5倍以上.偏头痛的发作频率及严重程度与抑郁症状息息相关.不同程度的抑郁症状对头痛相关的痛觉信号传导的影响也不同,在这些信号从丘脑传递到皮质的过程中易受到神经内分泌网络失调的影响.神经内分泌网络在参与偏头痛共病抑郁中起到十分重要的作用.因此,探究神经内分泌网络在共病中的发病机制可为筛选更加合适的偏头痛共病抑郁药物提供理论依据.

Migraine is the most common type of primary headache with disabling brain dysfunction.The prevalence of the migraine in Chinese population is 9.3%,and the ratio of female to male is 3∶1,which seriously affect people′s quality of life.Depression is one of the most common psychiatric disorders in migraine comorbidity.Compared with non-migraine patients,the risk of depression comorbidity in migraine patients is more than 2.5 times higher.The frequency and severity of migraine are closely related to depressive symptoms.Depressive symptoms have different effects on headache-related pain signal transduction,which is susceptible to neuroendocrine network disorders in the process of transmission from thalamus to cortex.Neuroendocrine network plays an important role in the depression of migraine comorbidity.Therefore,exploring the pathogenesis of neuroendocrine network in comorbidity provides a theoretical basis for screening more suitable depressive drugs for migraine comorbidity.