肠道菌群对肿瘤的影响及中医药调节作用研究进展

Research Progress on Effects of Gut Microbioma on Tumor and Regulation of Chinese Herbs

肠道菌群是人体内复杂的微生态系统,被称为人体第二基因组。肠道菌群失调通过循环、代谢、免疫等方式对大肠癌、肝癌、胃癌、乳腺癌、胰腺癌等恶性肿瘤的发生发展发挥重要作用。中药通过调节肠道菌群协同抗癌药物、增加机体免疫力、抑制炎性因子表达及促进益生菌活性等方式发挥抗肿瘤作用。就肠道菌群与恶性肿瘤的关系及其发生发展机制,中医药通过调节肠道菌群抗肿瘤的研究进行总结和分析,就这一热点问题进行综述。

The intestinal flora, called the second genome of the human body, is a complex micro-ecological system in the human body. Intestinal flora imbalance plays a significant role in the development of colorectal cancer, liver cancer, gastric cancer, breast cancer, pancreatic cancer and other malignant tumors through circulation, metabolism and immunity. Traditional Chinese medicine exerts anti-tumor effects by regulating intestinal flora and synergistic anti-cancer drugs, increasing immunity, inhibiting the expressions of inflammatory factors and promoting probiotic activity. In this essay, we summarized and analyzed the researches about the relationship between intestinal flora and malignant tumors and its development mechanism. Traditional Chinese medicine plays an anti-tumor effect through the regulation of intestinal flora and this popular topic was reviewed.