九味镇心颗粒联合盐酸舍曲林治疗广泛性焦虑的临床观察

Clinical Observation on Treatment of Generalized Anxiety with Jiuwei Zhenxin Granules Combined with Sertraline Hydrochloride

目的:探讨九味镇心颗粒联合盐酸舍曲林治疗广泛性焦虑的临床效果。方法:广泛性焦虑患者96例按照随机数字的方法分为对照组和观察组,每组48例,对照组给予盐酸舍曲林进行治疗,观察组在对照组治疗方法基础上给予九味镇心颗粒,对两组治疗前后的汉密尔顿焦虑量表(HAMA)评分,血清超氧化物歧化酶(SOD)和丙二醛(MDA)水平进行比较,对治疗效果和不良反应情况进行比较。结果:经过治疗后,对照组的HAMA评分从(21.37±3.86)分降低到(11.61±2.03)分,SOD从(56.08±8.69)IU/mL升高到(62.36±5.55)IU/mL,MDA从(10.36±2.11)μmol/L降低到(9.15±1.07)μmol/L,观察组的HAMA评分从(22.08±4.01)分降低到(8.51±1.26)分,SOD从(57.11±7.64)IU/mL升高到(68.61±6.68)IU/mL,MDA从(11.38±3.08)μmol/L降低到(8.34±1.18)μmol/L,观察组的变化幅度大于对照组,数据差异均具有统计学意义(t=8.989,-4.986,3.523,P<0.05),观察组的治疗效果优于对照组,数据差异具有统计学意义(z=-2.148,P<0.05);两组的口干[18.75%(9/48)VS. 14.58%(7/48)],头晕[16.67%(8/48)VS. 14.58%(7/48)],便秘[20.83%(10/48)VS. 18.75%(9/48)],呕吐[6.25%(3/48)VS. 8.33%(4/48)],头痛[4.17%(2/48)VS. 6.25%(3/48)],恶心[10.42%(5/48)VS. 14.58%(7/48)]发生率数据差异均不具有统计学意义(χ~2=0.300,0.079,0.066,0.075,0.075,0.381,P>0.05)。结论:使用九味镇心颗粒联合盐酸舍曲林治疗广泛性焦虑的患者,可以缓解患者的症状,降低氧化应激水平,提升治疗效果,安全性良好,值得在临床工作中推广。

Objective:To explore the clinical effect of Jiuwei Zhenxin Granules combined with sertraline hydrochloride in the treatment of generalized anxiety. Methods:Ninety-six patients with generalized anxiety disorder were selected. They were randomly divided into control group and observation group, with 48 patients in each group. Patients in the control group were given sertraline hydrochloride for treatment, while those in the observation group were given Jiuwei Zhenxin Granules on the basis of the treatment methods in the control group. The Hamilton Anxiety Scale(HAMA) scores, serum superoxide dismutase(SOD) and malondialdehyde(MDA) levels before and after treatment were compared between the two groups. The therapeutic effects and adverse reactions were compared. Results:After treatment, the HAMA score of the control group decreased from(21.37±3.86) points to(11.61±2.03) points, and SOD increased from(56.08±8.69)IU/mL to(62.36±5.55)IU/mL, MDA reduced from(10.36±2.11)μmol/L to(9.15±1.07)μmol/L. The HAMA score of the observation group decreased from(22.08±4.01) points to(8.51±1.26) points, SOD increased from(57.11±7.64)IU/mL to(68.61±6.68)IU/mL, and MDA reduced from(11.38±3.08)μmol/L to(8.34±1.18)μmol/L. The change of the observation group was larger than that of the control group, and the data was statistically significant(t=8.989,-4.986, 3.523, P<0.05). The therapeutic effect of the observation group was better than that of the control group, and the data were statistically significant(z=-2.148, P<0.05). The incidence of dry mouth[18.75%(9/48) VS. 14.58%(7/48)], dizziness[16.67%(8/48) VS. 14.58%(7/48)], constipation[20.83%( 10/48) VS. 18.75%(9/48)], vomiting[6.25%(3/48) vs. 8.33%(4/48)], headache[4.17%(2/48) vs. 6.25%(3/48)], nausea[10.42%(5/48) vs. 14.58%(7/48)] of the two groups was not statistically significant(χ~2=0.300, 0.079, 0.066, 0.075, 0.075, 0.381, P>0.05). Conclusion:The use of Jiuwei Zhenxin Granules combined with sertraline hydrochloride in the treatment of patients with generalized anxiety can alleviate the symptoms of patients, reduce the level of oxidative stress, improve the therapeutic effect and has good safety. It is worthy of promotion in clinical work.