粘质沙雷菌对碳青霉烯类抗菌药物耐药机制研究进展

Advances in study on resistance mechanism of Serratia marcescens to carbapenems

近年来耐碳青霉烯类粘质沙雷菌的耐药率和临床分离率在逐步上升,这给医院感染防控和临床抗感染治疗工作带来了极大的挑战。粘质沙雷菌可通过携带碳青霉烯酶基因,外膜孔道蛋白的改变或缺失,主动外排机制,抗菌药物作用靶点的改变,整合子的作用等产生耐药性,本文结合国内外文献对其碳青霉烯类药物耐药机制做一综述,为临床抗细菌治疗及新型药物研发提供理论依据。

In recent years,the resistance rate and clinical isolation rate of carbapenem-resistant Serratia marcescens have been gradually increasing,which has brought great challenges to the control and clinical treatment of nosocomial infection.S.marcescens can produce drug resistance by carrying the carbapenemase genes,alteration or deletion of outer membrane pore protein,active efflux mechanism,change of target of antibacterial drug and action of integron.The mechanisms of resistance to carbapenems are reviewed based on the literatures abroad and at home,which may provide theoretical basis for clinical antibacterial treatment and development of novel drugs.