慢性心力衰竭合并肺部感染患者血清H-FABPS100A12及炎症因子变化分析

目的 观察慢性心力衰竭合并肺部感染患者血清心型脂肪酸结合蛋白(H-FABP)、钙结合蛋白S100A12(S100A12)及炎症因子(IL-6、TNF-α、CRP)的变化,为临床诊治提供参考.方法 选取2015年1月至2018年5月慢性心力衰竭患者80例为心力衰竭组(CHF组),其中并发肺部感染(感染亚组)与单纯心力衰竭无肺部感染(非感染亚组)患者各40例,同时选取健康体检40例为对照组,比较各组间血清H-FABP、S100A12、IL-6、TNF-α及CRP的水平.结果 CHF组患者H-FABP、S100A12、IL-6、TNF-α及CRP水平均高于对照组,差异均有统计学意义(P<0.05).在CHF组中,感染亚组患者H-FABP、S100A12、IL-6、TNF-α及CRP水平分别为(7.89±1.24)ng/ml、(39.81±6.34)ng/ml、(28.26±4.87)pg/ml、(21.36±4.18)ng/L和(28.15±3.61)mg/L均高于非感染亚组患者的(6.34±1.08)ng/ml、(26.32±4.88)ng/ml、(20.14±2.84)pg/ml、(13.41±3.24)ng/L和(20.04±3.16)mg/L,差异均有统计学意义(P<0.05).随着心力衰竭程度的加剧,其H-FABP、S100A12、IL-6、TNF-α及CRP水平差异明显增大,差异均有统计学意义(P<0.05).结论 慢性心力衰竭合并肺部感染患者外周血H-FABP、S100A12和炎症因子水平明显升高,且与肺部感染及心力衰竭严重程度密切相关.

Objective To observe the changes of serum H-FABP,S100A12 and inflammatory factors of chronic heart failure(CHF)patients complicated with pulmonary infections,so as to provide guidance for clinical diagnosis and treatment.Methods A totally of 80 CHF patients complicated with pulmonary infections who were treated in hospitals from Jan 2015 to May 2018 were chosen as the CHF group,including 40 patients complicated with pulmonary infection(infected subgroup)and 40 cases without pulmonary infection(non-infected subgroup),meanwhile,40 healthy people who received physical examination were set as the control group.The levels of serum H-FABP,S100A12,IL-6,TNF-αand CRP were observed and compared.Results The levels of H-FABP,S100A12,IL-6,TNF-αand CRP were significantly higher in the CHF group than these was in the control group(P<0.05).In the CHF group,the levels of H-FABP,S100A12,IL-6,TNF-αand CRP of the infected subgroup were respectively(7.89±1.24)ng/ml,(39.81±6.34)ng/ml,(28.26±4.87)pg/ml,(21.36±4.18)ng/L and(28.15±3.61)mg/L higher than(6.34±1.08)ng/ml,(26.32±4.88)ng/ml,(20.14±2.84)pg/ml,(13.41±3.24)ng/L and(20.04±3.16)mg/L of the non-infected subgroup,and there was significant difference(P<0.05).With the increase of the degree of patients with heart failure,the levels of H-FABP,S100A12,IL-6,TNF-αand CRP were significantly increased,the difference was statistically significant(P<0.05).Conclusion The levels of H-FABP,S100A12 and inflammatory factors are remarkably elevated in the chronic heart failure patients,which is closely associated with the pulmonary infection and the degree of heart failure.