立体定向体部放射治疗早期非小细胞肺癌患者的疗效与预后因素分析

Effect and prognostic factors of stereotactic body radiotherapy in patients with early non-small cell lung cancer

目的探讨立体定向体部放射治疗(SBRT)早期非小细胞肺癌(NSCLC)患者的疗效与影响预后的因素分析。方法选取2011年11月至2013年11月在南京医科大学附属江宁医院住院治疗的NSCLC患者共98例,根据入院顺序单双数分为对照组与SBRT组,对照组给予常规放疗,SBRT组给予SBRT,放疗结束后比较2组近期疗效疗效与5年总生存率。采用Logistic多因素分析影响生存的相关因素。结果放疗结束后,SBRT组患者疗效优于对照组(χ^2=10.060,P=0.002)。多因素分析显示年龄、肿瘤直径、治疗方式为影响预后的独立影响因素。结论与常规放疗比较,SBRT对于NSCLC患者近期疗效具有更好的提升,并可明显提高其5年累积生存率。年龄、肿瘤直径、治疗方式与5年生存有关,应对具有这些高危因素的患者进行早期预防并采取一定干预措施。

Objective To investigate the efficacy and prognostic factors of stereotactic body radiotherapy(SBRT)in patients with early non-small cell lung cancer(NSCLC).Methods Selected hospitalized in our department,a total of 98 patients with non-small cell lung cancer,according to admission order and odd number is divided into control group and SBRT group,control group given conventional radiotherapy,SBRT group given radiotherapy,short-term efficacy and 5-year cumulative survival rates were compared between the two groups after radiotherapy,and use the logistic multifactor analysis the relevant factors that affect survival.Results After radiotherapy,the curative effect of SBRT group was better than that of control group(χ^2=10.060,P=0.002).Multivariate analysis showed that age,tumor diameter,and treatment were independent influencing factors for survival.Conclusions Compared to conventional radiotherapy,SBRT has better short-term efficacy and significantly improves the 5-year cumulative survival rate of patients with NSCLC.Age,tumor diameter,and treatment were associated with 5-year survival.Therefore,early prevention and intervention measures should be taken for patients with these high-risk factors.