健康体检者脂蛋白磷脂酶A2和髓过氧化物酶的参考范围及其临床意义

Reference Range and Clinical Significance of Lipoprotein Phospholipase A2 and Myeloperoxidase in Healthy Persons

目的 研究苏州地区健康体检者血清中脂蛋白磷脂酶A2(Lp-PLA2)和髓过氧化物酶(MPO)的浓度水平,探讨健康人群血清中Lp-PLA2和MPO的参考范围及其临床应用价值.方法 选取236 名健康体检者,其中男性123 名,平均年龄(43.7±16.6)岁,女性113 名,平均年龄(42.8±14.0)岁,采用苏州博源医疗科技有限公司生产的试剂进行测定,建立健康体检者血清中Lp-PLA2和MPO的参考范围,并对其临床应用进行分析.结果 男性的Lp-PLA2和MPO平均浓度水平高于女性,但差异无统计学意义(P>0.05);随着年龄的增加,Lp-PLA2和MPO平均浓度水平均呈上升的趋势;健康人群血清中Lp-PLA2的参考范围为<695.3 U/L,MPO的参考范围为<111.0 ng/mL.结论 该研究初步建立了苏州地区健康人血清中Lp-PLA2和MPO的参考范围,为临床上评估健康体检者是否有心血管疾病风险提供了依据.

Objective To study the concentrations of lipoprotein phospholipase A2 (Lp-PLA2) and myeloperoxidase (MPO) in serum of healthy people in Suzhou area, and to explore the reference range and clinical application value of serum Lp-PLA2 and MPO. Methods 236 cases of healthy physical examination were selected, including 123 males (mean age (43.7±16.6) years) and 113 females (mean age (42.8±14.0) years). The reference range of Lp-PLA2 and MPO in serum of healthy physical examination patients was established by using reagents produced by Suzhou Boyuan Medical Technology Co., Ltd., and their clinical application was analyzed. Results The average concentration of Lp-PLA2 and MPO in males was higher than that in females, but there was no significant difference. With the increase of age, the average concentration of Lp-PLA2 and MPO increased. The reference range of Lp-PLA2 in serum of healthy people was <695.3 U/L, and the reference range of MPO was <111.0 ng/mL. Conclusion The reference range of Lp-PLA2 and MPO in serum of healthy people in Suzhou area is established, which provides a basis for clinical evaluation of cardiovascular disease risk in healthy people.