血塞通注射液联合早期康复训练对急性脑梗死患者的疗效观察

Observation on the Curative Effect of Xuesaitong Injection Combined with Early Rehabilitation Training on Patients with Acute Cerebral Infarction

目的观察血塞通注射液联合早期康复训练对急性脑梗死患者的临床疗效.方法选取2017年6月-2018年12月入院接受治疗的急性脑梗死患者80例,按照随机数表法分为对照组和观察组各40例,两组患者入院初均给予降压、降脂、溶栓、退热、改善微循环等对症支持治疗.观察组在基本对症支持治疗基础上给予血栓通注射液静脉滴注以及早期康复训练.疗程均为2周.分别于治疗前后观察统计NIHSS及ADL评分变化情况并进行分析,免疫比浊法检测两组治疗前后血清CRP浓度,ELISA法检测血液TNF-α指标变化.结果两组患者治疗前NIHSS评分比较差异无统计学意义(P>0.05),治疗后两组患者NIHSS评分明显降低,与治疗前比较差异有统计学意义(P<0.05),且观察组治疗后NIHSS评分情况显著优于对照组治疗后(P<0.05);治疗后ADL评分均显著优于治疗前(P<0.05),且观察组治疗后ADL评分情况显著优于对照组治疗后(P<0.05);两组患者治疗前血清CRP及TNF-α浓度比较差异无统计学意义(P>0.05).治疗后,两组患者血清CRP和TNF-α浓度均较治疗前有显著降低(P<0.05);且治疗后观察组血清CRP及TNF-α浓度显著低于对照组治疗后(P<0.05).结论血塞通注射液联合早期康复治疗,可以有效降低慢性炎症对脑缺血再灌注的损伤,对急性脑梗死患者疗效显著,值得临床推广.

Objective To observe the clinical effect of Xuesaitong injection combined with early rehabilitation training on patients with acute cerebral infarction. Methods 80 patients with acute cerebral infarction admitted to the Fourth Affiliated Hospital of China Medical University from June 2017 to December 2018 were selected and divided into the control group and the observation group with 40 patients in each group according to the random number table method. Patients in the two groups were given symptomatic support treatment such as hypotension, lipid-lowering, thrombolysis, antipyretic and microcirculation improvement at the beginning of admission. The observation group received intravenous infusion of Xuesaitong injection and early rehabilitation training on the basis of symptomatic support treatment. The course of treatment was 2 weeks. Changes in NIHSS and ADL scores were observed and analyzed before and after treatment. Serum CRP concentrations were detected by immunopreturbidimetry before and after treatment, and changes in blood TNF-α were detected by ELISA. Results There was no significant difference in NIHSS scores between the groups before treatment (P>0.05), and the NIHSS scores of the groups after treatment were significantly lower than those before treatment (P<0.05), and the NIHSS scores of the observation group after treatment were significantly better than those of the control group after treatment (P<0.05). ADL scores after treatment were significantly better than those before treatment (P<0.05), and ADL scores after treatment in the observation group were significantly better than those after treatment in the control group (P<0.05). There was no difference in serum CRP and TNF-α concentrations between the groups before treatment (P>0.05). After treatment, serum CRP and TNF-α concentrations in each group were significantly lower than before treatment (P<0.05). Conclusion Xuesaitong injection combined with early rehabilitation therapy can effectively reduce the injury of chronic inflammation to cerebral ischemia reperfusion, and has a significant effect on patients with acute cerebral infarction, which is worthy of clinical promotion.