外周神经损伤致神经病理性疼痛的机制研究进展

Review on the Mechanism of Neuropathic Pain Caused by Peripheral Nerve Injury

神经病理性疼痛(neuropathic pain, NPP)是躯体神经系统原发性的损害或疾病引起的疼痛,临床症状表现为自发痛、痛觉过敏及触诱发痛.NNP发病率高,约占慢性疼痛的1/5,且病因复杂,发病机制尚不明确,临床治疗仍是未攻克的难题.该文综述了近五年来外周神经损伤致NPP的发病机制相关研究,主要是与其相关的中枢机制、外周机制以及作用于其间的细胞因子和信号通路.

Neuropathic pain, defined as the pain caused by the damage or a lesion of the somatosensory system, has some symptomatic manifestations such as spontaneous pain, hyperalgesia and tactile abnormal pain. In view of its complicated etiology and the unclear pathogenesis, neuropathic pain is still a problem in clinical treatment. This article aims to review the recent progress in the pathogenesis of neuropathic pain during the past five years, and discuss the central mechanism, peripheral mechanism, the cytokines and signaling pathways involved in the pathogenesis of neuropathic pain.