ABCA1促胆固醇流出防治动脉粥样硬化的机制及调控

The mechanism and regulation of ABCA1 in preventing atherosclerosis through promoting cholesterol efflux

动脉血管的炎症反应和胆固醇的积累是动脉粥样硬化形成的高危因素,因此抑制巨噬细胞炎症反应和促进胆固醇流出已成为治疗动脉粥样硬化的有效途径。三磷酸腺苷结合盒转运体A1(ATP binding cassette transporter A1,ABCA1)能将细胞内游离胆固醇转运给贫脂的载脂蛋白A-I,从而促进高密度脂蛋白的形成,介导胆固醇的流出miRNA作为一种非编码的微小RNA,通过降解靶基因mRNA或阻碍其翻译,发挥ABCA1转录后的调控作用。因此探究ABCA1的作用机制及调控有利于动脉粥样硬化的有效防治。

The risk factors of atherogenesis are the inflammatory reaction of arterial vessels and the accumulation of cholesterol,so it has been exploited as a therapeutic way for atherosclerosis(AS)through inhibiting the inflammatory reactions of macrophages and prmoting cholesterol efflux.ATP binding cassette transporter A1(ABCA1)mediates the transport of cellular free cholesterol to lipid-free apolipoprotein A-I(ApoAI)facilitating the formation of high density lipoproteins(HDL),further mediating cholesterol efflux.miRNA as a noncoding microRNA,which can degrade mRNA of target genes or impede its translation,plays an important role in the post-transcriptional regulation of ABCA1.So exploring the mechanism and regulation of ABCA1 is beneficial for us to prevent and treat AS effectively.