血清淀粉样蛋白A1与急性心肌梗死的相关性

Correlation between serum amyloid A1(SAA1) and acute myocardial infarction

急性心肌梗死(acute myocardial infarction,AMI)作为冠状动脉急性、持续性缺血缺氧所致心肌细胞缺血坏死,多数是因为在冠状动脉不稳定斑块基础之上,动脉不稳定斑块破裂,从而继发血栓形成,引起冠状动脉血管持续、完全性阻塞的一种心血管急症。血清淀粉样蛋白A(serum amyloid A,SAA)是反应性淀粉样原纤维的血浆前体和敏感的急性期反应物,其作为急性时相反应物在疾病状态下参与动脉粥样硬化斑块的形成并在AMI的发生中的发挥作用及SAA在相关炎性反应疾病中的相关性。

The acute myocardial infarction(AMI)as acute myocardial ischemia and necrosis caused by acute ischemia and hypoxia,mostly due to unstable coronary plaques.A block of rupture,which is followed by thrombosis,causes a cardiovascular emergency after continuous and complete obstruction of coronary vessels.Serum amyloid A(SAA)is a plasma precursor of reactive amyloid fibrils and a sensitive acute phase reactant.It is involved in the formation of atherosclerotic plaques in disease states as an acute phase reactant and plays a role in the development of acute myocardial infarction and the correlation of serum amyloid A in related inflammatory response diseases.