心力衰竭中能量代谢紊乱及治疗的进展

Advances in energy metabolism disorder and treatment in heart failure

心力衰竭是大多数心血管疾病的终末阶段,发病率和病死率较高,严重危害人类的健康。心力衰竭的发病机制复杂,尽管不同原发病导致心力衰竭的机制存在差异,但心肌代谢异常、能量利用障碍是共同作用途径。目前改善心力衰竭患者异常的心肌能量代谢已成为治疗心力衰竭的有效手段,受到临床医师的广泛关注。因此,本文就心力衰竭与心肌能量代谢之间的关系及心肌能量代谢药物的应用进行综述,增进医务工作者对心力衰竭及其治疗的理解。

Heart failure(HF)remains a major cause of morbidity and mortality and is a growing healthcare burden worldwide.HF is a shared chronic phase of a multitude of cardiac diseases.Athough the complicated pathogenesis and mechanisms of HF caused by various primary diseases,the alterations in myocardial energy substrate metabolism are a hallmark of HF and are associated with an energy deficit in the failing heart.Targeting myocardial energetics in the viable and potentially salvageable tissue may be particularly effective in the treatment of HF and have been widely concerned in clinical applications.In this review,the association between HF and myocardial energy metabolism and the application of myocardial energy metabolism drugs are focus on.