血栓通注射液辅助治疗高龄缺血性脑卒中临床研究

Clinical Study on Xueshuantong Injection in Adjuvant Treatment for Senile Patients with Ischemic Stroke

目的:观察血栓通注射液辅助治疗对高龄缺血性脑卒中患者神经功能、血液流变学的影响。方法:选取296例高龄缺血性脑卒中患者为研究对象,按随机数字表法分为对照组和研究组,每组148例。对照组予常规对症支持治疗,研究组在对照组治疗基础上联合血栓通注射液治疗,2组均治疗4周。比较2组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、改良Barthel指数评分及血液流变学指标。结果:研究组总有效率92.57%,高于对照组的82.43%,差异有统计学意义(P<0.05)。治疗后,2组NIHSS评分均较治疗前降低(P<0.05),改良Barthel指数评分均较治疗前升高(P<0.05);研究组NIHSS评分低于对照组(P<0.05),改良Barthel指数评分高于对照组(P<0.05)。治疗后,2组全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原水平均较治疗前降低(P<0.05);研究组全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原水平均低于对照组(P<0.05)。结论:血栓通注射液辅助治疗高龄缺血性脑卒中,可以促进患者神经功能恢复,提升生活自理能力,改善血液流变学指标。

Objective:To observe the effect of Xueshuantong injection on nerve function and hemorheology in adjuvant treatment for senile patients with ischemic stroke.Methods:Selected 296 cases of senile patients with ischemic stroke as study objects and divided them into the control group and the research group according to the random number table,with 148 cases in each group.The control group was given routine symptomatic supportive treatment,while the research group was additionally given the combined treatment with Xueshuantong injection.Both groups received the treatment for four weeks.Compared the clinical effect,the scores of national institutes of health stroke scale(NIHSS) and modified Barthel indexes and the indexes of hemorheology in the two groups.Results:The total effective rate was 92.57% in the research group,being higher than that of 82.43% in the control group,the difference being significant(P <0.05).After treatment,NIHSS scores in the two groups were decreased when compared with those before treatment(P <0.05),and the scores of modified Barthel indexes were increased when compared with those before treatment(P <0.05);NIHSS scores in the research group were lower than those in the control group(P <0.05),and the scores of modified Barthel indexes were higher than those in the control group(P <0.05).After treatment,the levels of whole high blood viscosity,whole low blood viscosity,plasma viscosity and fibrinogen in the two groups were all decreased when compared with those before treatment(P <0.05);the levels whole high blood viscosity,whole low blood viscosity,plasma viscosity and fibrinogen in the study group were lower than those in the control group(P <0.05).Conclusion:The application of Xueshuetong injection in adjuvant treatment for senile patients with ischemic stroke can promote the recovery of nerve function of patients,enhance their self-care ability and improve the hemorheology.