补肺纳肾汤联合西药治疗慢性阻塞性肺气肿稳定期临床研究

Clinical Study on Bufei Nashen Tang Combined with Western Medicine for Chronic Obstructive Pulmonary Disease at Stable Stage

目的:观察补肺纳肾汤联合西药治疗慢性阻塞性肺气肿稳定期的临床疗效,以及对患者外周血肿瘤坏死因子-α(TNF-α)、血小板衍生生长因子-B(PDGF-B)的影响。方法:选取62例慢性阻塞性肺气肿稳定期患者,按随机数字表法分为对照组和观察组各31例。对照组给予常规西药治疗,观察组在对照组基础上联合补肺纳肾汤治疗,2组均连续治疗1个月。治疗前后记录中医证候积分,测量用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼气流速(PEF),检测TNF-α、PDGF-B水平,观察不良反应发生情况。结果:治疗后,2组咳嗽、喘息、咯痰积分均较治疗前降低(P<0.05);观察组咳嗽、喘息、咯痰积分均低于对照组(P<0.05)。治疗后,2组FVC、FEV1及PEF水平均较治疗前升高(P<0.05);观察组3项肺功能指标水平均高于对照组(P<0.05)。治疗后,2组TNF-α、PDGF-B水平均较治疗前降低(P<0.05);观察组TNF-α、PDGF-B水平均低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补肺纳肾汤联合西药治疗慢性阻塞性肺气肿稳定期,可以改善患者的中医证候和肺功能,降低外周血TNF-α、PDGF-B水平,药物安全性较高,值得推广应用。

Objective:To observe the clinical effect of Bufei Nashen tang combined with western medicine for chronic obstructive pulmonary disease at stable stage and its effect on the levels of tumor necrosis factor-a(TNF-a)and platelet derived growth factor-B(PDGF-B)in the peripheral blood of patients.Methods:Selected 62 cases of patients with chronic obstructive pulmonary disease at stable stage and divided them into the control group and the observation group according to the random number table,with 31 cases in each group.The control group was treated with routine western medicine,while the observation group was additionally given Bufei Nashen tang.Both groups received continuous treatment for a month.Recorded the Chinese medicine syndrome scores before and after treatment,measured the forced vital capacity(F VC),the forced expiratory volume in one second(FEV1)and the peak expiratory flow(PEF),detected the levels of TNF-a and PDGF-B and observed the incidence condition of adverse reactions.Results:After treatment,the scores of cough,wheezing and expectoration in the two groups were all decreased when compared with those before treatment(P<0.05);the scores of cough,wheezing and expectoration in the observation group were all lower than those in the control group(P<0.05).After treatment,the levels of FVC,FEV1 and PEF in the two groups were all increased when compared with those before treatment(P<0.05);the levels of three lung function indexes in the observation group were all higher than those in the control group(P<0.05).After treatment,the levels of TNF-αand PDGF-B in the two groups were decreased when compared with those before treatment(P<0.05);the levels of TNF-αand PDGF-B in the observation group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence condition of adverse reactions in the two groups(P>0.05).Conclusion:The application of Bufei Nashen tang combined with western medicine for chronic obstructive pulmonary disease at stable stage can improve the Chinese medicine syndrome of patients,enhance the lung function and reduce the levels of TNF-a and PDGF-B in the peripheral blood.It has relatively higher drug safety and is worthy of promotion and application.