清胰汤对急性重症胰腺炎患者临床指标的影响及机制浅探

Brief Exploration of the Effect and Mechanism of Qingyi Tang on Clinical Indexes in Patients with Acute Severe Pancreatitis

目的:探讨清胰汤对急性重症胰腺炎患者临床指标影响及机制。方法:将收治的90例急性胰腺炎患者根据随机分配原则均分成2组各45例,对照组实施常规综合治疗,观察组在常规综合治疗上加用清胰汤进行治疗。比较2组患者的血清淀粉酶、脂肪酶,相关炎性细胞因子及临床疗效。结果:治疗前,2组血淀粉酶、血脂肪酶比较,差异无统计学意义(P>0.05)。治疗后,2组血淀粉酶、血脂肪酶水平均较治疗前减低,观察组较对照组降低更明显,差异有统计学意义(P<0.05)。治疗前,2组肿瘤坏死因子-α(TNF-α)、白细胞介素-1 (IL-1)及白细胞介素-8 (IL-8)水平比较,差异无统计学意义(P>0.05)。治疗后,2组TNF-α、IL-1及IL-8水平均较治疗前降低,且观察组上述指标较对照组降低,差异有统计学意义(P<0.05)。治疗前,2组CD4^+、CD8^+及CD4^+/CD8^+比较,差异无统计学意义(P>0.05)。治疗后,CD4^+、CD4^+/CD8^+在观察组中的水平高于对照组,而CD8^+水平则较对照组降低,组间比较,差异有统计学意义(P<0.05)。治疗后,观察组治疗总有效率为95.56%,优于对照组的82.22%,差异有统计学意义(P<0.05)。结论:清胰汤能够有效抑制机体炎症因子的产生,阻碍血清炎性因子对机体的损害,进而实现对急性重症胰腺炎的缓解和治疗,改善患者临床症状,临床疗效显著。

Objective:To study the effect and mechanism of Qingyi tang on clinical indexes in patients with acute severe pancreatitis.Methods:Enrolled 90 cases of patients with acute pancreatitis and divided them into two groups according to the principle of random allocation,with 45 cases in each group.The control group received the routine comprehensive treatment and the observation group was additionally given Qingyi tang on the basis of routine comprehensive treatment.Compared the serum amylase and lipase,related inflammatory cytokines and clinical effect in the two groups.Results:Before treatment,there was no significant difference being found in the comparison of blood amylase and blood lipase in the two groups(P> 0.05).After treatment,the levels of blood amylase and blood lipase in the two groups were decreased when compared with those before treatment and the decrease in the observation group was more obvious than that in the control group,difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of tumor necrosis factor(TNF-a),interleukin-1(IL-1) and interleukin-8(IL-8) in the two groups(P> 0.05).After treatment,the levels of TNF-a,IL-1 and IL-8 in the two groups were all decreased when compared with those before treatment and the indexes mentioned above in the observation group were lower than those in the control group,difference being significant(P <0.05).Before treatment,there was no significant difference being found in the comparison of CD4^+,CD8^+and CD^4+/CD8^+ in the two groups(P> 0.05).After treatment,the levels of CD4^+and CD4^+/CD8^+in the observation group were higher than those in the control group,while the levels of CD8^+were decreased when compared with those in the control group;there is significant difference being found in the comparison between the two groups(P <0.05).After treatment,the total effective rate was 95.56% in the observation group,being better than that of 82.22% in the control group,difference being significant(P <0.05).Conclusion:The application of Qingyi tang can effectively inhibit the production of inflammatory reactions in the body and hinder the damage of serum inflammatory factors to the body,then achieve the relief and treatment of acute severe pancreatitis and improve the clinical symptoms of patients.It has obvious clinical effect.