脂溶性维生素辅助阿奇霉素治疗小儿支原体肺炎临床疗效及安全性

Clinical efficacy and safety of fat-soluble vitamin-assisted azithromycin in the treatment of children with mycoplasmal pneumonia

目的探讨脂溶性维生素辅助阿奇霉素治疗小儿支原体肺炎临床疗效及安全性。方法选取2017年3月—2018年10月本院收治的支原体肺炎患儿82例作为研究对象,随机数表法分为常规组和干预组两组,每组各41例。常规组进行阿奇霉素治疗,干预组进行脂溶性维生素辅助阿奇霉素治疗。比较两组患儿疗效及相关药物不良反应发生率。结果干预组患者治疗总有效率显著高于常规组(97.56%vs.82.93%,P<0.05)。两组腹痛腹泻、头晕、皮疹及恶心呕吐相关不良反应发生率比较,差异无统计学意义(P>0.05)。结论脂溶性维生素辅助阿奇霉素治疗小儿支原体肺炎能协助提高患儿临床疗效,并且不增加相关不良反应发生率,有重要治疗价值。

Objective To explore the clinical efficacy and safety of fat-soluble vitamin-assisted azithromycin in the treatment of children with mycoplasmal pneumonia.Methods Selected 82 case of children with mycoplasmal pneumonia admitted to our hospital from March 2017 to October 2018 as studying objects,they were randomized into a regular group(azithromycin treatment,41 cases)and intervention group(fat-soluble vitamin-assisted azithromycin treatment,41 cases).The efficacy of the two groups of children and the incidence of adverse drug reactions were compared.Results The total effective rate of treatment in the intervention group was significantly higher than that in the conventional group(97.56% vs.82.93%,P<0.05).There was no significant difference in the incidence of adverse reactions such as abdominal and diarrhea,dizziness,rash and nausea and vomiting between the regular group and the intervention group(P>0.05).Conclusions The treatment of pediatric mycoplasmal pneumonia with fat-soluble vitamin-assisted azithromycin could help improve the clinical efficacy of children.However,it does not increase the incidence of related adverse reactions,so that it has important therapeutic value.