归脾汤加减用于不寐证合并焦虑抑郁患者的效果观察

Effect of Guipi Decoction on Insomnia Complicated with Anxiety and Depression

[目的]研究归脾汤加减用于不寐证合并焦虑抑郁患者的效果观察。[方法]选取肇庆市第一人民医院2018年1月-12月116例不寐证合并焦虑抑郁患者为研究对象,抽签随机分为观察组与对照组,均58例,对照组采取常规西药治疗,观察组在对照组基础上联合归脾汤加减治疗,比较两组治疗前后睡眠质量、焦虑、抑郁评分及不良反应发生率。[结果]两组治疗后PSQI评分均呈显著降低趋势,与前一时点比较差异有统计学意义(P<0.05),观察组治疗后1周、2周、1月PSQI评分显著低于对照组(P<0.05);两组治疗前SAS及SDS评分比较差异无统计学意义(P>0.05),治疗后两组SAS、SDS评分均显著低于治疗前(P<0.05),观察组SAS、SDS评分显著低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。[结论]归脾汤加减用于不寐证合并焦虑抑郁治疗疗效显著,可有效改善睡眠质量及患者情志状态,且具有较高安全性。

[Objective]To study the effect of Guipi Decoction on insomnia with anxiety and depression.[Method]From January to December 2018,116 patients with insomnia and anxiety and depression were selected as subjects and were randomly divided into observation group and control group,58 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with Guipi Decoction on the basis of the control group.The sleep quality,anxiety,depression score and incidence of adverse reactions were compared between the two groups before and after treatment.[Result]After treatment,the PSQI scores of both groups showed a significant decreasing trendand there was a significant difference compared with those before treatment(P<0.05).The PSQI score of the observation group was significantly lower than that of the control group in 1 and 2 weeks and 1 month after treatment(P<0.05).There was no significant difference in SAS or SDS scores between the two groups before treatment(P>0.05).After treatment,the SAS and SDS scores of the two groups were significantly lower than those before treatment(P<0.05),while the SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).[Conclusion]Guipi Decoction is effective in the treatment of insomnia combined with anxiety and depression.It can effectively improve sleep quality and emotional state of patients,and has high safety.