风湿痹痛膏质量控制研究

Preliminary study on quality standard of Fengshibitong ointment

目的:对风湿痹痛膏进行初步质量标准研究。方法:采用TLC定性鉴别该复方制剂中炒白芍、醋延胡索,并采用HPLC对主要成分芍药苷的含量进行测定。结果:炒白芍、醋延胡索TLC图斑点清晰,阴性无干扰;芍药苷在0.005~0.800 mg/mL范围内线性关系良好,平均加样回收率为100.5%(RSD值为1.75%)。结论:本研究所建立的方法简便可靠,重复性好,适用于风湿痹痛膏的质量控制。

Objective:The preliminary study on the quality standard of Fengshibitong ointment was carried out.Methods:TLC was used to qualitatively identify fried Radix Paeoniae Alba and Rhizoma Corydalis with vinegar in the compound preparation,and the content of paeoniflorin was determined by HPLC.Results:The TLC images of fried Radix Paeoniae Alba and Rhizoma Corydalis with vinegar were clear and negative without interference.The linear relationship of paeoniflorin was good in the range of 0.005~0.800 mg·mL^-1,and the average recovery rate was 100.5%(RSD value was 1.75%).Conclusion:The method was simple,reliable and reproducible.It was suitable for the quality control of Fengshibitong ointment.