电针对改善黄体功能不全性不孕症患者子宫内膜容受性效果

Clinical effect of electroacupuncture for improving endometrial receptivity of infertility women induced by luteal phase deficiency

目的:探讨电针对黄体功能不全性不孕症患者子宫内膜容受性效果。方法:70例黄体功能不全性不孕症患者随机分为电针治疗组(35例)和对照组(35例),观察排卵日子宫内膜厚度、形态及内膜下血流指数,黄体期血清雌二醇、孕酮、整合素αvβ3水平;并随访统计妊娠率。结果:治疗后治疗组排卵期子宫内膜厚度(9.86±1.09 mm)高于对照组(7.03±1.12mm),A型子宫内膜比例高于对照组;子宫内膜下血流搏动指数(PI)及阻力指数(RI)均低于对照组;孕酮改善水平优于对照组,妊娠率(41.7%)高于对照组(20.0%)。雌二醇改善水平两组无差异,整合素αvβ3水平与孕酮水平无相关性(P>0.05)。结论:电针治疗可改善黄体功能不全性不孕症患者子宫内膜容受性,提高妊娠率。

Objective:To discuss the effect of electroacupuncture for improving endometrial receptivity of infertility women induced by luteal phase deficiency.Methods:70 infertility women induced by luteal phase deficiency were randomly divided into study group and control group(35 cases in each group).The women in the study group were given electroacupuncture except to the treatment of women in the control group.The thickness,morphology,and subendometrial blood flow index of the endometrium of infertility women on ovulation day,and the serum levels of estradiol(E2),progesterone(P).and integrin αvβ3 of infertility women in luteal phase,and the pregnancy rate were observed between the two groups.Results:After treatment,the endometrial thickness of women on ovulation day in the study group was 9.86±1.09 mm,which was significant higher than that(7.03±1.12 mm)of women in the control group(P<0.05).The proportion of endometrial type A of women in the study group was significant higher than that of women in the control group,but the pulsatility index(PI)and resistance index(RI)of subendometrial blood flow of women in the study group were significant lower(P<0.05).The improvement of P level of women in the study group was better than that of women in the control group(P<0.05).The pregnancy rate of women in the study group was 41.7%,which was significant higher than that(20.0%)of women in the control group(P<0.05).There was no significant different in E2 improvement degree of women between the two groups,and there was no correlation between the levels of integrinαvβ3 and P level(P>0.05).Conclusion:Electroacupuncture can improve endometrial receptivity and increase the pregnancy rate of infertility women induced by luteal phase deficiency.