中枢神经系统mTOR信号通路与药物成瘾关系的研究进展

Research progress in relationships between mTOR signaling pathway and drug addiction in central nervous system

药物成瘾属于一种慢性复发性脑疾病。反复的药物暴露会导致脑环路产生神经适应性变化,进而出现强迫性觅药行为。在生物体内,信号通路转导级联的放大会介导中枢神经系统奖赏环路的重塑。研究发现,哺乳动物雷帕霉素靶点(mTOR)信号通路与药物成瘾引起的神经适应性和奖赏效应直接相关。本文就mTOR信号通路及其与药物成瘾关系的研究进展作一综述,为深入探索药物成瘾的分子调控机制提供理论依据。

Drug addiction is a chronic recurrent brain disease.Repeated drug exposure may lead to neuroadaptive changes in the brain loop,and obsessive-compulsive drug seeking behaviors.In vivo,the signal transduction cascade amplification pathway mediates the remodeling of the reward loop of the central nervous system.Related studies have shown that the mammalian target of rapamycin(m TOR)signaling pathway is directly related to drug addiction,inducing neural adaptation and reward effects.Therefore,the research progress in m TOR signaling pathway and relationships between drug addiction were reviewed,and the prospects of research on the molecular mechanism of drug addiction were discussed.