丹参酮ⅡA磺酸钠注射液联合二丁酰环磷腺苷钙对不稳定型心绞痛患者心电图及血清PAPP-A、sCD40L水平的影响

Effects of sodium tanshinone IIA sulfonate combined with dibutyryl cyclic adenosine monophosphate on electrocardiogram and serum levels of PAPP-A and sCD40L in patients with unstable angina pectoris

目的探究二丁酰环磷腺苷钙联合丹参酮ⅡA磺酸钠注射液对不稳定型心绞痛患者心电图及血清可溶性白细胞分化抗原配体(sCD40L)、妊娠相关蛋白A(PAPP-A)水平的影响。方法选取2015年9月至2018年11月西安市临潼区中医院不稳定型心绞痛患者110例,依据随机数表法分组,各55例。两组均予以常规治疗,在此基础上,实验组予以二丁酰环磷腺苷钙+丹参酮ⅡA磺酸钠注射液治疗。统计两组心电图疗效、临床疗效、不良反应,并对比治疗前后血清PAPP-A、sCD40L水平。结果实验组临床总有效率为89.09%、心电图总有效率为90.91%,较对照组74.55%、76.36%高(P<0.05);治疗前两组血清sCD40L、PAPP-A水平无明显差异(P>0.05);治疗后实验组血清sCD40L、PAPP-A水平均较对照组低(P<0.05);实验组不良反应率(20.00%)与对照组(12.73%)相比,无明显差异(P>0.05)。结论对不稳定型心绞痛患者联合采用二丁酰环磷腺苷钙、丹参酮ⅡA磺酸钠注射液治疗,可有效降低血清sCD40L、PAPP-A水平,提高心电图疗效,效果较为显著,且安全性较高。

Objective To investigate the effect of calcium dibutyryl adenosine monophosphate combined with tanshinoneⅡA sodium sulfonate injection on electrocardiogram and serum soluble leukocyte differentiation antigen ligand(sCD40 L)and pregnancy associated protein A(PAPP-A)levels in patients with unstable angina pectoris.Methods From September 2015 to November 2018,110 patients with unstable angina pectoris in Lintong District Hospital of Xi′an were selected and grouped according to the random number table method,55 cases each.Both groups were treated with conventional therapy.On this basis,the experimental group was treated with dibutyryl cyclic adenosine monophosphate+tanshinoneⅡA sodium sulfonate injection.The electrocardiogram efficacy,clinical efficacy and adverse reactions of the two groups were compared,and the levels of serum PAPP-A and sCD40 L were compared before and after treatment.Results The total effective rate of the experimental group was 89.09%,and the total effective rate of ECG was 90.91%,which was higher than that of the control group(74.55%,76.36%)(P<0.05).There was no significant difference in serum sCD40 L and PAPP-A levels between the two groups before treatment(P>0.05);After treatment,the serum levels of sCD40 L and PAPP-A in the experimental group were lower than those in the control group(P<0.05).There was no significant difference in the adverse reaction rate(20.00%)between the experimental group and the control group(12.73%)(P>0.05).Conclusion The combination of dibutyryl cyclic adenosine monophosphate and tanshinoneⅡA sodium sulfonate injection in patients with unstable angina can effectively reduce the serum s CD40 L and PAPP-A levels and improve the electrocardiogram effect.The effect is more significant and the safety is higher.