T10 抗炎抗病毒

Reversible SAHH inhibitor ameliorates psoriasis-like skin inflammation in mice by modulating keratinocyte differentiation and reducing inflammatory infiltration via differentially regulating DNA methylation of GATA3 and LCN2 promoters,OBJECTIVE To investigate the anti-psoriatic molecular mechanisms of DZ2002.METHODS We performed genome-wide DNA methylation analysis by whole-genome bisulfite sequencing(WGBS)to investigate Cp G methylation alteration in skin of imiquimod(IMQ)-induced psoriasis-like murine model topically treated with DZ2002.Immunohistochemical analysis and flow cytometry examination were used to detect skin infiltration of immune cells.