摘要
持续炎症-免疫抑制-分解代谢综合征(PICS)是在全身性感染或非感染如创伤、烧伤、急性胰腺炎等进入慢性危重症阶段,以持续炎症反应、免疫抑制、蛋白质高分解代谢为特点的一组临床综合征。PICS患者免疫抑制、持续炎症及蛋白质高分解代谢之间存在复杂的交互对话,相互促进,互为因果。厘清PICS免疫、炎症和代谢之间的内在联系,具有重要临床意义。
Persistent inflammation-immunosuppression catabolism syndrome(PICS) is charactered by an immunocatabolic phenotype of persistent inflammation, immunosuppression, and catabolism in patients with chronic critical illness as a result of sepsis, trauma, burn, acute pancreatitis and so on. There is a complex interactive crosstalk between immune, inflammation and catabolism. It is of great clinical significance to clarify the internal association among immunity, inflammation and metabolism.
作者
刘军
Liu Jun(Department of Critical Care Medicine,Suzhou Municipal Hospital,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215001,China)
出处
《中华重症医学电子杂志》
2019年第4期302-306,共5页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
基金
江苏省苏州市科技发展计划项目（SS201874）
江苏省第五期“333工程”科研项目（BRA2016070）
苏州市卫生计生委科技项目（LCZX201607）
苏州市科技计划项目(SYS201569)
关键词
持续炎症-免疫抑制-分解代谢综合征
慢性危重症
炎症
固有免疫
获得性免疫
分解代谢
Persistent in ammation-immunosuppression catabolism syndrome
Chronic critical illness
In ammation
Innate immune
Acquired immune
Catabolism
