生物标志物对急性胰腺炎严重程度的早期预测

Advance of biological markers in study on early prediction value of acute pancreatitis

急性胰腺炎是全球范围内三大消化道疾病之一,根据其严重程度可分为轻度急性胰腺炎、中度重症急性胰腺炎、重度急性胰腺炎。中、重度急性胰腺炎病情重、进展迅速、病死率高。早期识别急性胰腺炎严重程度并尽早加强护理与治疗,可改变患者病程、住院时间及病死率。生物标志物具有标本容易获取、检测重复性好、稳定性高等优点,寻找有效的早期评估急性胰腺炎病情的生物标志物有助于胰腺炎的诊疗。本文就生物标志物对急性胰腺炎严重程度的早期预测研究进展做一综述。

Acute pancreatitis is one of the three most important diseases of the digestive system in the worldwide. It can be categorized into mild acute pancreatitis(MAP), moderately severe acute pancreatitis(MSAP) and severe acute pancreatitis(SAP). MSAP and SAP are severe, rapid progress and high mortality disease. Early recognition of the severity of pancreatitis and early appropriate care can change the course of disease, short the hospital stay and reduce mortality. Biological markers have attracted much attention due to their accessibility, high reproducibility and stability. Finding out the effective biomarkers for early assessment of acute pancreatitis is helpful for diagnosis and treatment. We reviewed the advances of biological marker for AP severity early prediction.