深圳市妊娠合并甲状腺疾病妇女的尿碘分析

Analysis of urinary iodine in pregnant women with thyroid disease in Shenzhen

目的了解深圳市妊娠合并甲状腺疾病妇女尿碘水平,为指导合理补碘提供科学依据。方法以2017年1月至2019年3月到北京大学深圳医院内分泌科就诊的170名妊娠合并甲状腺疾病妇女为研究对象,按照是否患有甲状腺功能亢进症(简称甲亢)分为甲亢组(84例)和非甲亢组(86例)。在正常饮食条件下留取晨尿,尿碘检测采用过氧乙酸四甲基联苯胺氧化显色法,尿碘<150μg/L为碘不足,150~249μg/L为碘适宜。结果深圳市妊娠合并甲状腺疾病妇女尿碘中位数为143.9μg/L,略低于碘适宜水平下限。其中甲亢组尿碘中位数为116.6μg/L,为碘不足水平;非甲亢组尿碘中位数为181.6μg/L,为碘适宜水平。甲亢组和非甲亢组尿碘比较差异有统计学意义(Z=-2.261,P<0.05)。结论深圳市妊娠合并甲亢妇女尿碘水平偏低。

Objective To study the urinary iodine level of pregnant women with thyroid disease in Shenzhen,and to provide scientific basis for rational iodine supplementation.Methods A total of 170 pregnant women with thyroid diseases who visited Department of Endocrinology,Peking University Shenzhen Hospital from January 2017 to March 2019 were selected as the subjects,they were divided into hyperthyroidism group(84 cases)and non-hyperthyroidism group(86 cases)according to whether they had hyperthyroidism or not.Morning urine sample was collected under normal dietary conditions;urinary iodine was detected by peroxyacetic acid tetramethylbenzidine oxidation colorimetry.Urinary iodine<150μg/L was iodine deficiency and 150-249μg/L was appropriate iodine.Results The median of urinary iodine of pregnant women with thyroid disease in Shenzhen was 143.9μg/L,which was slightly lower than the lowest limit of the appropriate iodine level.The median of urinary iodine in hyperthyroidism group was 116.6μg/L,which was at the iodine deficiency level;the median of urinary iodine in non-hyperthyroidism group was 181.6μg/L,which was at the appropriate iodine level.There was significant difference in urinary iodine levels between hyperthyroidism group and non-hyperthyroidism group(Z=-2.261,P<0.05).Conclusion The urinary iodine of pregnant women with hyperthyroidism in Shenzhen is slightly low.