线粒体质量控制系统作为心力衰竭潜在治疗靶点的研究进展

Mitochondrial quality control system as a therapeutic target for treating heart failure

线粒体质量控制主要通过线粒体蛋白降解、囊泡转运和自噬机制3个层次来维持线粒体稳态,线粒体生物合成、动力学以及钙离子在该过程中起到重要调节作用.一般情况下,质量控制网络能够协调运转.近年来研究发现,线粒体功能失调与心力衰竭的发生密切相关.为了深入了解线粒体的功能,文中对线粒体质量控制方式、调节因素及其在心力衰竭中的作用和潜在靶向治疗应用进行综述.

The mitochondrial quality control system maintains mitochondrial homeostasis mainly through protein degradation,vesicle transport,and mitophagy.Mitochondrial biosynthesis,dynamics,and calcium ion play key regulative roles in mitochondrial quality control.Under normal conditions,the mitochondrial quality control system can work well.In recent years,studies have found that mitochondrial dysfunction is closely associated with the occurrence of heart failure.In order to understand mitochondrial function,this paper reviews mitochondrial quality control methods,regulatory factors and their potential therapeutic applications in heart failure.